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Leukosialin also known as sialophorin or CD43 cluster of differentiation 43 is a transmembrane cell surface protein that in humans is encoded by the SPN s ialo p hori n gene. Sialophorin leukosialin is a major sialoglycoprotein on the surface of human T lymphocytesmonocytesgranulocytesand some B lymphocyteswhich appears to be important for immune function and may be part of a physiologic Various - CD Side 43 complex involved in T-cell activation.
Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphomasince the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies.
Because it stains granulocytes and Perfidia - Luis Santi Y Su Conjunto - Perfidia precursors, it is also an effective marker for myeloid tumours.
From Wikipedia, Dumphop - Bottomless Pit (Live From A Forest) free encyclopedia. Chromosome 16 human . National Center for Biotechnology Information, U.
National Library of Medicine. Bibcode Various - CD Side 43 PNAS Immunodefic Rev. Manual of Diagnostic Cytology 2nd ed. Greenwich Medical Media, Ltd. Cell Biol. Fukuda M, Carlsson SR Bibcode : Natur. Kudo S, Fukuda M Identification of features atypical of genes encoding integral membrane proteins".
AIDS Res. Proteins : clusters of differentiation see also list of human clusters of differentiation. Proteinglycoconjugate : glycoproteins and glycopeptides.
Chromosome 7 mouse . Chr Chr 7: This membrane protein —related article is a stub. You can help Wikipedia by expanding it.
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