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Manipulation - Tumor

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The extracellular interstitial pH pHe of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity.

Doxorubicin is a weak base chemotherapeutic agent that is commonly used in combination chemotherapy to clinically treat breast cancers. This report demonstrates that MCF-7 human breast cancer cells in vitro are more susceptible to doxorubicin toxicity at pH 7. Furthermore 31 P-magnetic resonance spectroscopy MRS has shown that the pHe of MCF-7 human breast cancer xenografts can be effectively and significantly raised with sodium bicarbonate in drinking water.

The bicarbonate-induced extracellular alkalinization leads to significant improvements in the therapeutic effectiveness of doxorubicin against MCF-7 xenografts in vivo. Although physiological resistance to weakly basic chemotherapeutics is Manipulation - Tumor in vitro and in theory, these data represent the Manipulation - Tumor in vivo demonstration of this important phenomenon.

National Center for Biotechnology InformationU. Journal List Br J Cancer v. Br J Cancer. Author information Article notes Copyright and License information Disclaimer.

CopyrightCancer Research Campaign. This article has been cited by other articles in PMC. Abstract The extracellular interstitial pH pHe of solid tumours is significantly more acidic compared to normal tissues.

Keywords: doxorubicin, acid-base balance, chemotherapy, MRS, bicarbonate. Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med. High-dose chemotherapy with autologous peripheral blood progenitor cell support for primary breast cancer in patients with involved axillary lymph nodes. Bone Marrow Transplant. Synergistic effects of adriamycin and TALL cell therapy against a human gastric carcinoma in vivo.

Anticancer Res. Cancer Treat Rep. Manipulation - Tumor blood flow influences combined radiation Manipulation - Tumor doxorubicin treatments. Radiother Oncol. Determination of cell number in monolayer cultures.

Anal Biochem. Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs. Am J Physiol. Studies of human tumors by MRS: a review. NMR Biomed. A general approach to selection of multiple cubic volume elements using the ISIS technique. Magn Reson Med. Effect of water and bicarbonate loading in patients with chronic renal failure. Clin Nephrol. Invest New Drugs. Plasmalemmal pH-gradients in drug-sensitive and Diggin’ On You (L.A.’s Live Remix) - TLC - We Love TLC MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy.

Biochem Pharmacol. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Weak acids, weak bases and intracellular pH. Respir Physiol. Cell biological mechanisms of multidrug resistance in tumors. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line.

Effect of ingested sodium bicarbonate on muscle force, fatigue, and recovery. J Appl Physiol Aug; 83 2 — On the origin of cancer cells. The relevance of tumour pH to the Manipulation - Tumor of malignant disease. Support Center Support Center.

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  1. Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell‐based immunotherapy. Daluthgamage Patsy Himali Wijesekera. Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan.
  2. Mouse tumor-models support the significance of cognate interactions between CD4 T cells and macrophages. In an aggressive breast tumor-mouse model ILproducing CD4+ T lymphocytes indirectly promoted invasion and subsequent metastasis of mammary adenocarcinomas by regulating the phenotype and effector function of tumor-associated mightworkerfedicoifyn.infoinfo by:
  3. Aug 01,  · The purpose of this study was to test the hypothesis that longitudinal O2 gradients in tumor affect response to manipulation of oxygenation. Previously we showed that pO2 is higher on the fascial than the tumor surface of the RAc rat mammary carcinoma when growing in a dorsal skin-fold window chamber, reflecting a longitudinal oxygen mightworkerfedicoifyn.infoinfo by:
  4. Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. Tumor hypoxia has long been considered as a detrimental factor for the response to irradiation. In order to improve the sensitivity of tumors cells to radiation therapy, tumor hypoxia may theoretically be alleviated by increasing the oxygen Cited by:
  5. Jul 08,  · The effects of autonomic innervation of tumors on tumor growth remain unclear. Here we developed a series of genetic techniques to manipulate autonomic innervation in a tumor- Cited by: 3.
  6. Manipulating Tumor Acidification as a Cancer Treatment Strategy Mark F. McCarty, BA and Julian Whitaker, MD Abstract Manipulation of the extracellular and/or intracellular pH of tumors may have considerable potential in cancer therapy. The extracellular space of most tumors is mildly acidic, owing to exuberant production of lactic acid.
  7. Enhancement of chemotherapy by manipulation of tumour pH. Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med. .
  8. Cancer Manipulation Potential. The Cancer sign of the Zodiac represents a sensitive and emotion person. These people are clearly in tune with their inner selves, consistently able to analyze their minds efficiently in time. Some of their characteristics include being kind, helpful, loyal, and protective. Family is their main priority, and they.

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